The Effect of Cefazolin on the Gut Microbiome of Female Rats After Spinal Cord Injury.

ABSTRACT: Spinal cord injury (SCI) is a devastating neurological state that could lead to motor, sensory, and autonomic dysfunction. In addition to its direct impact on the central nervous system, SCI exerts systemic effects, including disruption of gut homeostasis and alterations in the gut microbiota, which can contribute to sustained inflammation and hinder functional recovery. While antibiotic administration during the acute phase of SCI is clinically indicated, it may exacerbate microbial dysbiosis. In this study, we investigate the combined effects of SCI and cefazolin treatment on the gut microbiome of female rats. Animals were assigned to three groups: NAÏVE (no intervention), SHAM (cefazolin only), and INJURY (T10 spinal cord contusion plus cefazolin). Cefazolin was administered for seven d

SUBMITTER: Pagan-Rivera LH 

PROVIDER: S-EPMC12566097 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature