A Comparative Study of Five Target Volume Definitions for Radiotherapy in Glioblastoma Multiforme.

ABSTRACT: Background and Objectives: This study aimed to compare target volumes and organ-at-risk (OAR) doses using five different volume definitions in radiotherapy (RT) planning of patients with glioblastoma multiforme (GBM). Materials and Methods: Rigid image fusion was performed using simulation computed tomography and postoperative magnetic resonance imaging scans of 20 patients with GBM. Volumetric modulated arc therapy (VMAT) plans were generated according to three two-phase protocols-American Brain Tumor Consortium (ABTC), North Central Cancer Treatment Group/Alliance (NCCTG/Alliance), and Radiation Therapy Oncology Group/NRG (RTOG/NRG)-and two single-phase protocols-European Organisation for Research and Treatment of Cancer (EORTC) and European Society for Radiotherapy and Onc

SUBMITTER: Ibis K 

PROVIDER: S-EPMC12566177 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature