Sandalwood Sesquiterpene (<i>Z</i>)-α-Santalol Exhibits In Vivo Efficacy Against <i>Madurella mycetomatis</i> in <i>Galleria mellonella</i> Larvae.

ABSTRACT: In continuation of our recent report on the in vitro activity of sandalwood essential oils and their major components, the sesquiterpenes (Z)-α- and -β-santalols, against the pathogenic fungus Madurella mycetomatis, causative agent of the neglected tropical disease eumycetoma, we have now tested these isolated constituents, as well as native Royal Hawaiian sandalwood essential oil obtained from Santalum paniculatum, for in vivo activity in a model system using infected Galleria mellonella larvae. Besides confirming the superior activity of (Z)-α-santalol over the (Z)-β-isomer and the crude essential oil in two further strains of M. mycetomatis in vitro, the former compound also turned out to extend the lifespan of the infected larvae

SUBMITTER: Abd Algaffar SO 

PROVIDER: S-EPMC12566311 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature