Neuron-Specific Enolase as a Biomarker for Selected Neurological and Psychiatric Disorders-A Systematic Review of the Literature.

ABSTRACT: Background and Objectives: Neuron-specific enolase (NSE) is an isoenzyme of enolase, of which the γ isoform is expressed in nerve cells. The activity of NSE occurs during late neuronal differentiation, which determines the specificity of the enzyme for neurodevelopmental cells. The activity of NSE is also observed in processes associated with neuronal damage. The aim of this study was to present the state of the art related to the knowledge, advances, and possible developmental directions in terms of the use of NSE as a biomarker in the diagnosis of selected neurological and mental disorders (NDs, MDs), with particular emphasis on ischemic stroke (IS) and psychotic disorders (PSDs). Materials and Methods: A literature review was performed using the PubMed, Embase, and Scopus

SUBMITTER: Sierakowska A 

PROVIDER: S-EPMC12566432 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature