Hair-Template Confinement Assembly of Nanomaterials Enables a Robust Single-Hair Surface-Enhanced Raman Spectrocopy Platform for Trace Analysis.

ABSTRACT: Surface-enhanced Raman spectroscopy (SERS) enables ultra-sensitive molecular detection and has broad analytical and biomedical applications; recent advances focus on high-performance substrates and innovative detection strategies. However, achieving controllable and reproducible substrate fabrication-particularly using natural templates such as hair-remains challenging, limiting SERS application in trace analysis and on-site detection. This study developed a single-hair in situ SERS platform using a natural hair template. Confinement within hair cuticle grooves and capillary-evaporation assembly enables dense arrangement of cetyltrimethylammonium bromide-coated Au nanorods and polyvinylpyrrolidone-coated Au nanoparticles, forming uniform plasmonic nanoarrays. Spectroscopy and microscopy an

SUBMITTER: Qin M 

PROVIDER: S-EPMC12566538 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature