MicroRNA Biomarkers in Paediatric Infection Diagnostics-Bridging the Gap Between Evidence and Clinical Application: A Scoping Review.

ABSTRACT:

Background

Distinguishing between bacterial and viral infections in children remains a significant challenge for clinicians. Traditional biomarkers have limited utility, often leading to antibiotic overprescription due to clinician uncertainty. With rising antimicrobial resistance, novel biomarkers are needed to improve diagnosis. This scoping review examines current host miRNA biomarkers for acute bacterial and viral infections in children (0-18), focusing on study methods, diagnostic metrics, and research gaps to support clinical translation.

Results

Of the 1147 articles identified, 36 studies were included. Notably, 72.2% of the studies originated from Asia, and the distribution across the paediatric age groups was relatively even. A total of 17 miRNAs were validated in a

SUBMITTER: Rodgers O 

PROVIDER: S-EPMC12566583 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature