Phage to ESKAPE: Personalizing Therapy for MDR Infections-A Comprehensive Clinical Review.

ABSTRACT: The proliferation of multidrug-resistant (MDR) ESKAPE pathogens-Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.-constitutes a critical global health crisis, rendering conventional antibiotics increasingly ineffective. This comprehensive review evaluates the re-emerging potential of bacteriophage therapy as a personalized treatment for infections caused by these organisms. Phages, being viruses that specifically infect and lyse bacteria, offer significant advantages, including high specificity that spares host microbiota, self-replication at the infection site, and potent activity against biofilms. This paper synthesizes current preclinical and clinical eviden

SUBMITTER: Marino A 

PROVIDER: S-EPMC12566643 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature