Integrated Network Pharmacology and Molecular Dynamics Reveal Multi-Target Anticancer Mechanisms of <i>Myrtus communis</i> Essential Oils.

ABSTRACT: Background: Cancer's multifactorial complexity demands innovative polypharmacological strategies that can simultaneously target multiple oncogenic pathways. Natural products, with their inherent chemical diversity, offer promising multi-target therapeutic potential. This study comprehensively investigates the anticancer mechanisms of Tunisian Myrtus communis essential oils (McEOs) using an integrated computational-experimental framework to elucidate their polypharmacological basis and therapeutic potential. Methods: McEO composition was characterized via GC-MS analysis. Antiproliferative activity was evaluated against HeLa (cervical), MCF-7 (breast), and Raji (lymphoma) cancer cell lines using MTT assays. A multi-scale computational pipeline integrated network pharmaco

SUBMITTER: Bayoudh A 

PROVIDER: S-EPMC12566675 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature