Immunomodulatory Effect of Raspberry (<i>Rubus idaeus</i> L.) Fruit Extracts on Activated Macrophages and Dysfunctional Vascular Endothelial Cells.

ABSTRACT: Background: Growing evidence highlights the beneficial effects of flavonoids, including anthocyanins, as key components in reducing cardiovascular risk, and emphasizes that incorporating anthocyanin-rich fruits into the daily diet significantly impacts public health. Methods: The effect of bioactive polyphenols from raspberry fruit (RBF) on molecular pathways in inflammation was studied in activated RAW 264.7 macrophages and their protective potential against endothelial dysfunction was analyzed using TNF-α-induced human umbilical vein endothelial cells (HUVECs). Results: The results have shown that RBF extract, along with its anthocyanin and polyphenol fractions, has a significant anti-inflammatory effect in macrophage cell culture by inhibiting the LPS-induced expres

SUBMITTER: Kowalska K 

PROVIDER: S-EPMC12566686 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature