Comparative Safety of Empirical Antibiotic Classes in Newly Hospitalized COVID-19 Patients.

ABSTRACT: Background: Empirical antibiotic use is common in hospitalized patients with COVID-19 despite the low prevalence of bacterial coinfection, raising concerns about antimicrobial resistance and inappropriate prescribing. However, the comparative safety of commonly used antibiotic classes in this context remains unclear. Methods: We conducted a retrospective cohort study using real-world clinical data standardized through the Observational Medical Outcomes Partnership Common Data Model from 1 January 2020 to 31 May 2025. Adults with confirmed COVID-19 who were administered empirical antibiotics on the admission day were included. Empirical antibiotic exposure was categorized as third-generation cephalosporins (3GCs), fluoroquinolones, or aminopenicillins with β-lactamase inhibito

SUBMITTER: Park K 

PROVIDER: S-EPMC12566716 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature