Formulation and Testing of Alginate Microbeads Containing <i>Salvia officinalis</i> Extract and Prebiotics.

ABSTRACT: Background/Objectives: This study aimed to develop an advanced oral delivery platform for Salvia officinalis (S. officinalis) extract by co-encapsulating it with inulin and pectin in alginate-based microbeads, formulated via ionic gelation. Methods: The microbeads were comprehensively characterized, including the assessment of morphology, particle size, encapsulation efficiency, swelling behavior, in vitro dissolution, and enzymatic stability, and Caco-2 cell-based assays for cytocompatibility, permeability, and transepithelial electrical resistance. Antioxidant capacity and anti-inflammatory effects were also evaluated. Results: The resulting microbeads (~275 µm) achieved > 90% encapsulation efficiency and exhibited pronounced swelling (~90%). The releas

SUBMITTER: Bodnar K 

PROVIDER: S-EPMC12566799 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature