Influence of Selected Hypromellose Functionality-Related Characteristics and Soluble/Insoluble Filler Ratio on Carvedilol Release from Matrix Tablets.

ABSTRACT: Background/Objectives: This study investigated how selected functionality-related characteristics (FRCs) of hypromellose (HPMC)-namely viscosity, hydroxypropoxy substitution, particle size, and the ratio of water-soluble (FlowLac^® 100) to water-insoluble (Avicel^® PH-102) fillers- affect the release of carvedilol from matrix tablets. Methods: Using a Central Composite Design (CCD) Design of Experiments (DoE), mixtures of HPMC QbD samples were prepared to achieve target HPMC FRC levels. Within the CCD, levels of FlowLac^® 100 and Avicel^® PH-102 were also varied. The mean and standard deviation of carvedilol release at each analyzed time point of the release profile were used as target variables for individual multiple linear regression

SUBMITTER: Ojstersek T 

PROVIDER: S-EPMC12566823 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature