Design of Polycation-Functionalized Resveratrol Nanocrystals for Intranasal Administration.

ABSTRACT: Background/Objectives: Nanocrystals (NCs) are a relatively underexplored yet adaptable platform with broad potential for various applications. Currently, the surface modification of NCs leads to the development of versatile platforms capable of enhancing targeted delivery potential and supporting the advancement of precision medicine. With this in mind, this study focused on the design and surface functionalization of a resveratrol (RSV) NC selected for its antioxidant and neuroprotective effects. Methods: The design of the RSV NC was assessed by the Quality by Design approach. With the aim of intranasal administration, we assessed the RSV NC functionalization with a cationic poly (amino acid) belonging to the class of cell-penetrating peptides. Both naked and surface-modifie

SUBMITTER: Bonaccorso A 

PROVIDER: S-EPMC12566871 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature