The value of cholangioscopy-guided bite-on-bite (-on bite) biopsies in indeterminate biliary duct strictures.

ABSTRACT:

Background

 Digital single-operator cholangioscopy (dSOC) has improved the diagnostic accuracy of indeterminate biliary duct strictures (IBDS) through targeted intraductal biopsy sampling. However, the optimal biopsy technique remains uncertain.

Methods

 This international, multicenter, prospective interventional study (November 2020-August 2022) included patients with IBDS undergoing dSOC. Stricture sampling involved obtaining at least four single biopsies and at least one bite-on-bite biopsy (BBB) in all patients. Definitive diagnosis was established by pathology outcomes and 1-year clinical follow-up. The primary outcome was the accuracy of both biopsy techniques.

Results

 89 patients were included, with 76 hilar strictures and 13 distal strictures. Technical succe

SUBMITTER: de Jong DM 

PROVIDER: S-EPMC12566887 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature