Genetic Characteristics of <i>Acinetobacter baumannii</i> Isolates Circulating in an Intensive Care Unit of an Infectious Diseases Hospital During the COVID-19 Pandemic.

ABSTRACT: During the COVID-19 pandemic, a significant increase in the spread of healthcare-associated infections (HAIs) and antimicrobial resistance (AMR) was observed. Acinetobacter baumannii, particularly carbapenem-resistant strains, poses a serious threat in intensive care units (ICUs). This study aimed to genetically characterize A. baumannii isolates from the ICU of an infectious diseases hospital repurposed for COVID-19 patient treatment. Whole-genome sequencing (WGS) was performed on 56 A. baumannii isolates from patients and environmental surfaces using the Illumina MiSeq platform. Bioinformatic analysis included multi-locus sequence typing (MLST), core-genome MLST (cgMLST), phylogenetic analysis, and in silico detection of antimicrobial resistance genes. Three sequence

SUBMITTER: Smirnova SS 

PROVIDER: S-EPMC12566897 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature