Homotypic Targeting of [⁸⁹Zr]Zr-Oxine Labeled PC3 and 4T1 Cells in Tumor-Bearing Mice.

ABSTRACT: Background/Objectives: Homotypic targeting refers to the ability of cells to preferentially interact with other cells of the same type. An understanding of how cells use homotypic targeting (self-homing) characteristics for tumor-targeting purposes may aid in the effective delivery of radionuclides or other drugs for imaging or therapeutic applications. Additionally, studies investigating the targeting properties of cells from the same lineage may shed light on this interesting mechanism, allowing it to be harnessed for other applications. The objective of this study was to assess the tumor-self targeting potential of PC3 prostate cancer and 4T1 breast cancer cells using a direct cell labeling technique, with a focus on evaluation of cellular labeling efficiency, cell viability, cel

SUBMITTER: Tekin V 

PROVIDER: S-EPMC12566915 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature