Whole-Genome Sequencing Analysis of Drug-Resistant <i>Salmonella Typhi</i> in Children.

ABSTRACT: Typhoid fever, caused by Salmonella enterica subsp. enterica serovar Typhi (S. typhi), remains a major public health concern, particularly in low-resource settings with poor sanitation. The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains have significantly complicated treatment, especially in vulnerable pediatric populations. This study aimed to characterize the genetic profiles of drug resistance in MDR and XDR S. typhi isolates from pediatric patients.

Methods

A cross-sectional study was conducted on 800 blood samples from pediatric typhoid patients. S. typhi isolates were identified using the BacT/ALERT 3D system, followed by culture on MacConkey and blood agar. Antimicrobial susceptibility was assessed

SUBMITTER: Riaz M 

PROVIDER: S-EPMC12566932 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature