Biocompatible Interpenetrating Network Hydrogels with Dually Cross-Linked Polyol.

ABSTRACT: Modern tissue regeneration strategies rely on soft biocompatible materials with adequate mechanical properties to support the growing tissues. Polymer hydrogels have been shown to be available for this purpose, as their mechanical properties can be controllably tuned. In this work, we introduce interpenetrating polymer networks (IPN) hydrogels with improved elasticity due to a dual cross-linking mechanism in one of the networks. The proposed hydrogels contain entangled polymer networks of covalently cross-linked poly(ethylene glycol) methacrylate/diacrylate (PEGMA/PEGDA) and poly(vinyl alcohol) (PVA) with two types of physical cross-links-microcrystallites and tannic acid (TA). Rheological measurements demonstrate the synergistic enhancement of the elastic modulus of the single PEGMA/PEGDA

SUBMITTER: Tuleuov UB 

PROVIDER: S-EPMC12567005 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature