Advanced Vaginal Nanodelivery of Losartan Potassium via PEGylated Zein Nanoparticles for Methicillin-Resistant <i>Staphylococcus aureus</i>.

ABSTRACT: Background/Objectives: PEGylated zein nanoparticles (PZNs) loaded with losartan potassium (LOS) were developed as a repurposed treatment for vaginal methicillin-resistant Staphylococcus aureus (MRSA) infection. PZNs were prepared using the ethanol injection method with different types and amounts of Brij^® surfactant. Methods: The prepared formulations were optimized using a D-optimal mixture design via Design-Expert^® software version 13. The assessed responses included entrapment efficiency (EE%), particle size (PS), and zeta potential (ZP). Results: The optimized PZNs, composed of 30 mg Brij^® O20 and 10 mg zein, exhibited spherical particles with an EE% of 90.58 ± 1.20%, PS of 200.81 ± 1.39 nm, PDI of 0.395 ± 0.01, and ZP

SUBMITTER: Albash R 

PROVIDER: S-EPMC12567013 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature