Targeting Melanogenesis with Postbiotics: An Integrated Zebrafish-Based Assessment of <i>Lactobacillus salivarius</i> BGHO-1 and <i>Lactobacillus paracasei</i> BGSJ2-8.

ABSTRACT: Skin hyperpigmentation disorders represent a major dermatological challenge, and safe alternatives to conventional depigmenting agents remain scarce. Probiotics and their postbiotic derivatives have emerged as promising natural candidates; however, only a few bacterial strains have been investigated for melanogenesis-inhibitory activity, and their true potential remains largely unexplored. Here, we report for the first time the biosafety profile and anti-melanogenic activity of Lactobacillus salivarius BGHO-1 and Lactobacillus paracasei BGSJ2-8, and assess their possible use in the treatment of skin hyperpigmentation. Two complementary zebrafish-based approaches were employed: (i) image-assisted analysis of pigmentation patterns, melanocyte morphology, and melanocytotoxicity,

SUBMITTER: Katona G 

PROVIDER: S-EPMC12567018 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature