<i>Campylobacter hepaticus</i> Transcriptomics Identified Genes Involved in Spotty Liver Disease (SLD) Pathogenesis.

ABSTRACT: Campylobacter hepaticus is the etiological agent of Spotty Liver Disease (SLD), a newly emerging bacterial disease of laying hens resulting in significant mortality and production losses primarily in free-range systems. Although its economic impact continues to grow, the molecular basis of C. hepaticus pathogenesis remains poorly understood. In this study, we conducted transcriptomic profiling of C. hepaticus in three host-relevant conditions, exposure to chicken bile, infection of a chicken liver hepatocellular carcinoma (LMH) cell line, and isolation from liver lesions of naturally infected chickens. Through RNA-seq analysis, we found unique gene expression signatures in each environment. In the bile, C. hepaticus exhibited differential expression of 412 genes

SUBMITTER: Bommineni V 

PROVIDER: S-EPMC12567157 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature