Anti-Photoaging Effects of a Standardized Hot Water Extract of <i>Petasites japonicus</i> Leaves in Ultraviolet B-Exposed Hairless Mice.

ABSTRACT: Background: Ultraviolet B (UVB) radiation accelerates skin aging by inducing oxidative stress, collagen degradation, and cellular senescence. Although Petasites japonicus is known for its antioxidant properties, its anti-photoaging potential remains underexplored. This research explored the protective properties of a hot water extract from P. japonicus leaves (KP-1) against photoaging caused by UVB exposure. Methods: Hairless mice were exposed to UVB three times per week and orally administered KP-1 for 13 weeks. Wrinkle formation, epidermal thickness, skin hydration, and collagen content were assessed. Protein expression related to MAPK/AP-1, TGF-β/Smad2/3, and p53/p21 pathways was analyzed by Western blotting. Results: KP-1 significantly reduced UVB-ind

SUBMITTER: Song HA 

PROVIDER: S-EPMC12567178 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature