Pulmonary Embolism After Acute Ischaemic Stroke (PEARL-AIS): Global Prevalence, Risk Factors, Outcomes, and Evidence Grading from a Meta-Analysis.

ABSTRACT: Objectives: Pulmonary embolism (PE) is an uncommon but potentially fatal complication of acute ischaemic stroke (AIS). Its global burden and prevention remain incompletely defined. We performed a systematic review and meta-analysis (PEARL-AIS) to estimate prevalence, risk factors, outcomes, and prophylactic efficacy, with GRADE evidence appraisal. Methods: Following PRISMA 2020 and MOOSE guidelines, five databases (PubMed, Embase, Cochrane, Scopus, Web of Science) were searched (1995-2024). The protocol was prospectively registered (OSF s25ny). Random-effects models (DerSimonian-Laird; REML sensitivity) were used to pool prevalence and odds ratios; heterogeneity was evaluated with I², Cochran's Q, and τ². Influence (leave-one-out) and subgroup analyses f

SUBMITTER: Chen D 

PROVIDER: S-EPMC12567275 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature