Intraoperative neural firing correlates with motor and cognitive features in Parkinson's disease.

ABSTRACT:

Objective

During deep brain stimulation (DBS) surgery for Parkinson's disease (PD), intraoperative microelectrode recordings (MERs) are frequently used to determine electrode positioning within the subthalamic nucleus (STN) and globus pallidus internus (GPi). Various patient characteristics might be associated with abnormal STN and GPi firing activity and thus influence electrode placement. In this study, the authors aimed to elucidate the relationship between preoperative dopamine responsiveness or changes in cognitive status and STN or GPi multiunit activity.

Methods

This retrospective cohort study included patients with PD undergoing awake STN (n = 74) or GPi (n = 63) DBS surgery with intraoperative MER at a single institution from 2013 to 2021. To control for the lead po

SUBMITTER: Hughes NC 

PROVIDER: S-EPMC12567315 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature