Improving Oxidative Stress Through a Wheat Aleurone-Rich Diet: Are Short-Chain Fatty Acids Possible Mediators?

ABSTRACT: Background/Objectives: Dietary fibers from cereals promote the production of short-chain fatty acids (SCFA), which have been linked to improved glucose and lipid metabolism, reduced inflammation, and decreased oxidative stress. Wheat aleurone, a bran fraction enriched in fermentable fibers and bioactive compounds, may enhance SCFA production, but clinical evidence remains limited. This study investigated whether a wheat aleurone-rich diet, compared with a refined wheat diet, modulates circulating SCFA concentrations and their relationship with oxidative stress in individuals at elevated cardio-metabolic risk. Methods: In a randomized, cross-over trial, 23 adults with abdominal obesity and at least one additional metabolic syndrome feature consumed isoenergetic diets enriched

SUBMITTER: Testa R 

PROVIDER: S-EPMC12567320 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature