Serum Proteomics Reveals Systemic Responses in <i>Didelphis aurita</i> Naturally Infected with <i>Hepatozoon</i> sp.

ABSTRACT: Didelphis aurita is a widely distributed neotropical marsupial frequently found in peri-urban environments and known to harbor various pathogens, including hemoparasites of the genus Hepatozoon. However, the systemic physiological responses of naturally infected individuals remain poorly understood. This study aimed to characterize the serum proteomic profile of Didelphis aurita naturally infected with Hepatozoon sp., providing insights into host-parasite interactions and potential biomarkers of infection. Serum samples were analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS), followed by functional annotation based on Gene Ontology and KEGG pathway enrichment. A total of 67 proteins were identified, 33 of which were exclusive to infected animals.

SUBMITTER: Orozco AMO 

PROVIDER: S-EPMC12567376 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature