Impact of Artificial Sweeteners on Inflammation Markers: A Systematic Review of Animal Studies.

ABSTRACT:

Background

Artificial sweeteners, widely used as non-nutritive sugar substitutes, are increasingly prevalent in ultra-processed products. Although promoted for weight management due to their minimal caloric content, their impact on systemic inflammation remains uncertain. This systematic review of animal studies aims to evaluate the association between artificial sweetener consumption and inflammatory biomarkers.

Methods

A systematic literature search was conducted up to May 2025 across PubMed, Web of Science, and Scopus, following PRISMA guidelines and registered in PROSPERO (CRD420251084004). Risk of bias was assessed using the ARRIVE guidelines and SCYRCLE's risk of bias tool.

Results

Thirty-seven animal studies were included: aspartame (n = 17), sucralose (

SUBMITTER: Raoul PC 

PROVIDER: S-EPMC12567400 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature