Disclosure of Genotype Information to Reduce Caffeine Intake in Slow Metabolizers: Findings from a Randomized Controlled Trial on Personalized Dietary Interventions.

ABSTRACT: Background/Objectives: This study evaluated whether personalized nutrition (PN) advice combined with disclosure of genetic information leads to a greater reduction in caffeine consumption than PN advice alone in slow caffeine metabolizers in the short and long terms. Additionally, Ecological Momentary Assessment (EMA) was considered for its potential to improve dietary intake assessment. Methods: In 2019-2021, 94 adults (aged 18-60 years, C allele carriers of rs762551 CYP1A2, consuming ≥ 200 mg/day caffeine), 63% of whom were women, participated in a twenty-week intervention. Participants were randomized to receive PN with genotype information (the intervention group, n = 55) or without it (the control group, n = 39). All participants were advised to limit caffeine int

SUBMITTER: Bulczak E 

PROVIDER: S-EPMC12567419 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature