A Polysaccharide-Rich Ingredient from <i>Hypericum perforatum</i> L. Ameliorates Depression-like and Post-Traumatic Stress Disorder-like Symptoms in Mouse Models.

ABSTRACT: Background/Objectives: Hypericum perforatum L. (H. perforatum), commonly known as St. John's wort, has been widely used in clinical practice to treat mental disorders. Previous studies and clinical applications have primarily focused on its alcohol-soluble ingredients. Our research was designed to investigate the physicochemical properties, antidepressant-like effects, and anti-post-traumatic stress disorder (PTSD)-like effects of the alcohol-insoluble polysaccharide-rich ingredients from H. perforatum. Meanwhile, the underlying mechanisms were elucidated. Methods: The physicochemical properties of two polysaccharide-rich ingredients, designated as HPP1 and HPP2, were characterized using colorimetric assay, capillary electrophoresis, high-performance gel

SUBMITTER: Jin ZJ 

PROVIDER: S-EPMC12567441 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature