Silica Containing Hybrids Loaded with Ibuprofen as Models of Drug Delivery Systems.

ABSTRACT: Background/Objectives: The present work deals with the sol-gel synthesis of hybrid materials based on a silica-polyvinylpyrrolidone (Si-PVP) system. Methods: The nanohybrids have been prepared using an acidic catalyst at ambient temperature. Ibuprofen (IBP) was used as a model substance in the obtained model drug systems, while tetraethyl orthosilicate (TEOS) was used as a silica precursor. Poly(vinylpyrrolidone) (PVP) and IBP were introduced into the reaction mixture as solutions in ethanol using two different approaches: (i) a direct introduction of a drug solution into the reaction mixture during sol-gel synthesis, and (ii) a solvent deposition technique. Results: XRD data provide evidence that IBP entrapped in the silica-PVP network is in an amorphous state. By SEM

SUBMITTER: Kostova Y 

PROVIDER: S-EPMC12567524 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature