Synthesis and Comparative Study of the Structure and Antibacterial Activity of Polygalacturonate Complexes with Ionic and Nanoparticulate Silver.

ABSTRACT: A series of silver-polygalacturonate complexes with improved structure and activity against bacterial infections was developed. Pure sodium polygalacturonate was obtained by saponification of a pectin precursor and identified by NMR as predominantly homogalacturonan (uronide content 95%). Polygalacturonate complexes with ionic and borohydride-reduced silver with a controllable metallic component were synthesized; the role of spontaneous Ag⁺ reduction was revealed. The presence of uniform 5 nm nanoparticles and negligible particulate by-products in the reduced complexes was verified. The complexes showed similar silver-normalized activity against non-resistant bacteria, irrespective of complex stoichiometry/silver state. Pharmaceutical silver proteinate with a similar nanoparticl

SUBMITTER: Nemtarev AV 

PROVIDER: S-EPMC12567555 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature