Influence of Prednisolone Treatment on Serum Bile Acid Concentrations in Cats.

ABSTRACT: While corticosteroids affect bile acid metabolism in humans and dogs, their impact on serum bile acids in cats is unknown. Moreover, the early effects of corticosteroids on liver enzyme activity in cats are not well understood. We prospectively studied seven healthy cats (4-7 years) treated with oral prednisolone (1.1-1.5 mg/kg, median 1.28 mg/kg PO daily) for 7 days. Serum bile acids and liver enzyme activities (ALT, AST, ALP, GGT) were measured before treatment (day 0) and at days 2, 3, 8, 10, and 14. Statistical analysis used the Friedman test with post hoc comparisons to baseline. At baseline, bile acids were within reference interval (1-6.5 μmol/L) (median 2.1 μmol/L, range 1-3.2) and increased significantly during treatment with prednisolone to a median of 5.3 μmol/L (range 1.8-8.7)

SUBMITTER: Pacheva M 

PROVIDER: S-EPMC12567590 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature