Functional Mutations in the <i>VRTN</i> Gene Influence Growth Traits and Meat Quality in Hainan Black Goats.

ABSTRACT: The VRTN (vertebrin) gene plays a crucial role in regulating thoracic vertebral number in mammals; however, its function in goats remains largely unexplored. This study aimed to investigate genetic variations in the VRTN gene in Hainan black goats (HNBGs) and evaluate their associations with growth and meat traits. Using whole-genome and Sanger sequencing, we identified four SNPs in the VRTN gene, including three missense mutations (p.Pro615Ser, p.Arg490Lys, p.Thr476Met) and one synonymous mutation (p.Asp688Asp). Tissue expression profiling revealed high VRTN mRNA expression in skeletal muscle and low expression in internal organs, suggesting a potential role in muscle development. Temporal expression analysis indicated dynamic regulation during growth, with hig

SUBMITTER: Xu M 

PROVIDER: S-EPMC12567611 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature