Causal Associations of Circulating Micronutrients With the Risk of Infertility: A Mendelian Randomization Study.

ABSTRACT: Infertility impacts 48 million couples globally, and accumulating evidence suggests that micronutrients potentially influence reproductive health. This Mendelian randomization study investigates causal relationships between 15 micronutrients and infertility in both males and females, aiming to complement existing nutritional epidemiology insights. Genetic association estimates for micronutrient biomarkers (including selenium, iron, β-carotene, calcium, magnesium, phosphorus, folate, vitamins B₆, B₁₂, C, D, zinc, copper, iodine, and manganese) and infertility phenotypes were derived from European-ancestry genome-wide association study (GWAS) cohorts. For causal inference, inverse-variance weighted MR served as the primary analytical method, supplemented by MR-Egger and

SUBMITTER: Zhang J 

PROVIDER: S-EPMC12567636 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature