<i>Exocarpium Citri Grandis</i> Ameliorates Metabolic Disorders by Inhibiting Inflammatory Responses and NLRP3 Inflammasome Activation.

ABSTRACT: Exocarpium Citri Grandis (ECG, known as Huajuhong in Chinese), as the fruit that can be used both as medicine and food, has gained attention for its hypolipidemic and anti-obesity effects. However, its lipid-lowering potential and ability to alleviate metabolic syndrome (MS) remain unexplored. This study aimed to confirm the therapeutic effects of ECG on postmenopausal MS and investigate its underlying mechanisms. An animal model of female postmenopausal MS was established using 8-week-old ovariectomized (OVX) mice. Starting from the third week after model establishment, the mice were orally administered at the doses of 25, 50, and 100 mg/kg for 12 consecutive weeks. HepG2 cells co-induced by oleic acid and palmitic acid (OA&PA) were used as an in vitro model. Ultra-high-perf

SUBMITTER: Chen T 

PROVIDER: S-EPMC12567642 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature