Characterization of the Hemagglutinin Gene of <i>Morbillivirus canis</i> in Domestic Dogs from the Mid-Western Area of Brazil.

ABSTRACT: Canine distemper virus (CDV) is a serious and often fatal disease caused by Morbillivirus canis, which affects domestic dogs and wild carnivores, with case-fatality rates reaching up to 47%. The hemagglutinin (H) protein mediates viral adsorption and shows high genetic variability, making it a valuable molecular marker. This study aimed to detect and characterize the H gene of CDV strains from 14 dogs with fatal neurological disease in the Brazilian states of Mato Grosso and Rondônia. Brain tissue was tested via RT-PCR for the nucleocapsid gene, and positive samples were amplified for the H gene. Ten complete H-gene sequences were obtained. Phylogenetic analysis revealed two distinct clusters within the South America I/Europe lineage: one related to strains from Uruguay and Argentin

SUBMITTER: Kavasaki ML 

PROVIDER: S-EPMC12567662 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature