Expression of L-Amino Acid Oxidase (Ml-LAAO) from the Venom of the <i>Micrurus lemniscatus</i> Snake in a Mammalian Cell System.

ABSTRACT: Animal venoms are rich in bioactive molecules with promising biotechnological potential. They comprise both protein and non-protein toxins. Among the protein toxins are enzymes, such as phospholipases A₂, proteases and L-amino acid oxidases (LAAOs). LAAOs exhibit antimicrobial, antiparasitic, antiviral, and anticancer effects, making them potential candidates for biotechnological applications. These activities are linked to their ability to catalyze oxidative reactions that convert L-amino acids into α-keto acids, releasing ammonia and hydrogen peroxide, which contribute to the immune response, pathogen elimination, and oxidative stress. However, in snakes of the Micrurus genus, LAAOs generally represent a small portion of the venom (up to ~7%), which limits their isolati

SUBMITTER: Costa AJO 

PROVIDER: S-EPMC12567790 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature