Inferring Geographic Spread of Flaviviruses Through Analysis of Hypervariable Genomic Regions.

ABSTRACT: The Flaviviruses Dengue virus (DENV), West Nile virus (WNV), Zika virus (ZIKV), and Yellow Fever virus (YFV), are mosquito-borne viruses that represent a persistent challenge to global health due to the emergence and re-emergence of outbreaks of significant magnitudes. Their positive-sense RNA genome, about 11,000 nucleotides long, encodes structural and nonstructural proteins. These viruses evolve rapidly through mutations and genetic recombination, which can lead to more virulent and transmissible strains. Although whole-genome sequencing is ideal for studying their evolution and geographic spread, its cost is a limitation. We investigated the genetic variability of DENV, ZIKV, WNV, and YFV to identify genomic regions that accurately reflect the phylogeny of the complete coding sequence

SUBMITTER: Sanchez-Nava J 

PROVIDER: S-EPMC12567808 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature