Assessing the Kynurenine-Tryptophan Ratio (KTR) and CYP1 Activity in Longnose (<i>Catostomus catostomus</i>) and White Suckers (<i>Catostomus commersonii</i>) Exposed to Petroleum-Derived Contaminants from the Alberta Oil Sands Region.

ABSTRACT: In the Alberta Oil Sands Region (AOSR), environmental stressors linked to oil sands industrial activity may have significant and species-specific impacts on local wildlife. This study evaluated the kynurenine-tryptophan ratio (KTR) as a potential biomarker for environmental exposure in longnose suckers (Catostomus catostomus) and white suckers (Catostomus commersonii) collected from various locations within the AOSR. The relationship between KTR and CYP1 enzyme activity (ethoxyresorufin-O-deethylase; EROD) was assessed alongside biometric indices, including gonadosomatic index (GSI), hepatic somatic index (HSI), and fat content. Both species exhibited increased EROD activity when exposed to oil sands natural deposits and potential industrial activity, indicating significant p

SUBMITTER: Jamshed L 

PROVIDER: S-EPMC12567817 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature