The Acute Immune Response in Sheep Following Immunization with <i>Toxoplasma gondii</i> Tachyzoites or Parasite-Derived Glycoconjugates.

ABSTRACT: Toxoplasmosis is a relevant parasitic infection in sheep, with ovine meat an important source of human exposure. Accurate detection of the early immune response to Toxoplasma gondii is essential for preventing reproductive losses and improving diagnostic strategies. This study evaluated the kinetics of the acute immune response in eighteen sheep experimentally exposed to live tachyzoites or immunized with parasite-derived glycoconjugates (GlyC). Animals were divided into three groups and injected with saline solution, tachyzoites, or glycoconjugates combined with an adjuvant. Infected sheep developed specific IgM antibodies against both lysate and glycoconjugate antigens from day 4, and IgG against glycoconjugates from day 12 post-infection. Glycoconjugate-immunized sheep produced I

SUBMITTER: Meira-Santos PO 

PROVIDER: S-EPMC12567891 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature