Differentiation of West Nile and Usutu Virus Infections by Antibodies Directed to the Non-Structural Protein 1.

ABSTRACT: The genus Orthoflavivirus (family Flaviviridae) comprises several important pathogens that are widespread across the globe, often co-circulating in many regions. In Austria, the closely related mosquito-borne West Nile (WN) and Usutu (USU) viruses have been detected since the early 2000s. Orthoflavivirus-neutralizing antibodies primarily target the major envelope protein E. However, due to their antigenic relationship, recurring contacts with different orthoflaviviruses can lead to the induction of broadly cross-reactive E-specific antibodies. These can pose a problem in the diagnosis and differentiation of orthoflavivirus infections. Therefore, we established immunological assays based on the non-structural protein 1 (NS1) to differentiate infections caused by WN and USU vir

SUBMITTER: Roßbacher L 

PROVIDER: S-EPMC12567941 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature