Metabolic Biomarkers for Lifespan Extension and Cellular Stress in <i>Saccharomyces cerevisiae</i> during Calorie Restriction and Quercetin Treatment.

ABSTRACT: As life expectancy increases, age-related diseases pose significant challenges in modern medicine. The molecular mechanisms of aging have been widely explored in mice, nematodes, human cells, and yeast. The budding yeast Saccharomyces cerevisiae has become the most widely employed eukaryotic model due to its short lifespan and well-characterized genetic and molecular profiles. However, research into the metabolite perturbations associated with lifespan extension has tended to focus on mutant or engineered yeast cells, and information regarding these processes in normal yeast cells remains scant. In this study, therefore, we investigated how aging affects the intracellular metabolites of S. cerevisiae during its growth and how these changes relate to lifespan extension induced

SUBMITTER: Mun MY 

PROVIDER: S-EPMC12567969 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature