Developing organ dysfunction diagnostic criteria for children with cancer and post-hematopoietic cell transplantation: protocol of systematic review.

ABSTRACT:

Background

The Pediatric Organ Dysfunction Information Update Mandate (PODIUM) proposed consensus criteria to define organ dysfunction in critically ill children. However, utilization of the PODIUM criteria in pediatric oncology patients and those who have received hematopoietic cell transplantation or cellular therapy (post-HCT/CAR) may inaccurately classify organ dysfunction in these patients due to differences in organ dysfunction etiology, pathophysiology, and risk factors for adverse outcomes. To address this gap, we report a study protocol to systematically review the performance of the PODIUM criteria for pediatric cancer and/or those treated with HCT and determine if adjustments are needed.

Objective

The objectives of this study will be to [1] identify evidence-based

SUBMITTER: Bashir M 

PROVIDER: S-EPMC12568018 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature