Neutralisation of the Immunoglobulin-Cleaving Activity of <i>Streptococcus equi</i> Subspecies <i>equi</i> IdeE by Blood Sera from Ponies Vaccinated with a Multicomponent Protein Vaccine.

ABSTRACT: Background:Streptococcus equi subspecies equi (S. equi) is the cause of strangles, one of the most prevalent diseases of horses worldwide. The disease is characterised by fever and the formation of abscesses in the lymph nodes of the head and neck, which can restrict the airway. A multicomponent subunit vaccine, Strangvac, has been shown to effectively reduce clinical signs of strangles and to reduce its incidence. Objective: The aim of this study was to determine the immune response against the immunoglobulin-cleaving endopeptidase IdeE, a key protective component within the vaccine and the ability of antibodies to neutralize the proteolytic activity of IdeE. Methods: An in vitro assay was developed to measure the functional inhibition of recombin

SUBMITTER: Righetti F 

PROVIDER: S-EPMC12568127 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature