Maternal Cigarette Smoke Exposure Does Not Impair Influenza Vaccine Responsiveness in Murine Offspring.

ABSTRACT:

Background/objectives

Environmental pollutants can profoundly affect immune development, yet their impact on offspring vaccine responsiveness remains poorly understood. To address this, we investigated the impact of maternal cigarette smoke (CS) exposure, a major contributor to household air pollution, on influenza vaccine responsiveness in offspring.

Methods

Pregnant dams were exposed to CS or air during gestation and lactation. Two weeks post-weaning, offspring received two influenza vaccinations. After the booster vaccination, vaccine-specific delayed-type hypersensitivity (DTH), serum immunoglobulins, and splenic T cells were analyzed.

Results

Vaccinated offspring exhibited robust DTH responses and comparable levels of vaccine-specific IgG1 and IgG2a, regardless o

SUBMITTER: Dehghani A 

PROVIDER: S-EPMC12568188 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature