An Intranasal Challenge Model in African Green Monkeys (<i>Chlorocebus aethiops</i>) for Mild-to-Moderate COVID-19 Disease Caused by Subvariant XBB.1.5.

ABSTRACT: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily causes mild to moderate respiratory illness in humans, but infection can also lead to long-term complications, including chronic fatigue, respiratory and cardiac issues, or even death. In November 2021, the emergence of the highly transmissible Omicron variant marked a significant shift in the pandemic, with its subvariants rapidly spreading and continuing to evolve worldwide. The continuing introduction of Omicron subvariants underscores the need for the development of up-to-date vaccines, as well as for appropriate animal models in which they can be evaluated. Among these subvariants, XBB.1.5 stands out for its ability to evade the immune response from previous infection or vaccination. The objective of this study was

SUBMITTER: Storm N 

PROVIDER: S-EPMC12568310 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature