Mapping of chromatin architecture and enhancer-promoter interactions in the cochlea.

ABSTRACT:

Introduction

Chromatin interactions, particularly those between promoters and distal enhancers, enable precise gene regulation in specialized tissues, like the cochlea in the inner ear. Disruptions in these long-range interactions between enhancers and gene promoters are linked to hereditary hearing loss. For many genes important to cochlear development and function, the distal regulatory elements that control their expression remain unknown. Identifying these elements and studying their regulatory roles is challenging due to their distance from target genes and the spatial complexity of chromatin architecture.

Methods

To address this, we employed Micro-C, a high-resolution chromatin conformation capture technique for mapping chromatin interactions, to construct a cochlea-sp

SUBMITTER: Ege T 

PROVIDER: S-EPMC12568336 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature