Mitochondrial dysfunction in PRRSV-2-infected macrophages.

ABSTRACT:

Introduction

Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most economically devastating viruses for the global swine industry. PRRSV has a known tropism for lung macrophages, where it causes impaired immune responses. This study evaluated the metabolic and immune profiles of primary porcine alveolar macrophages (PAMs) and pulmonary intravascular macrophages (PIMs) infected with different strains of PRRSV-2 isolated from North Carolina (NC) pig herds (NC134, NC18-9-7 referred to as NC174, and NC20-1 referred to as NC144), and VR2232, a PRRSV-2 prototype strain.

Materials and methods

Primary enriched mononuclear phagocytes were infected in vitro with NC134 and NC174, sorted, and processed. The total RNA was used for a transcriptomic approach

SUBMITTER: Vu Manh TP 

PROVIDER: S-EPMC12568354 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature