Combination of CRP and miRNA signature as a potential diagnostic strategy for Kawasaki disease.

ABSTRACT:

Background

Kawasaki disease is the leading cause of acquired heart disease in children, yet timely diagnosis remains difficult due to overlapping symptoms with other febrile illnesses.

Methods

In a retrospective case-control study of 38 children with Kawasaki disease and 44 febrile controls, we measured hematological parameters and C-reactive protein (CRP) using standardized analyzers and profiled seven serum microRNAs by qRT-PCR. Biomarkers showing significant differences were used to build logistic regression models with a 70/30 train-test split, and diagnostic accuracy was assessed by receiver operating characteristic analysis. Functional enrichment of miRNA targets was explored using network analysis.

Results

CRP and three microRNAs (miR-223-3p, miR-19a-3p, miR-18

SUBMITTER: Huang X 

PROVIDER: S-EPMC12568371 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature