CT-based habitat radiomics for preoperative differentiation of adenocarcinoma in situ/minimally invasive adenocarcinoma from invasive adenocarcinoma manifesting as ground-glass nodules: a multicenter study.

ABSTRACT:

Objectives

To develop a CT-based habitat radiomics model for preoperative differentiation of adenocarcinoma in situ/minimally invasive adenocarcinoma (AIS/MIA) from invasive adenocarcinoma (IAC) manifesting as ground-glass nodules (GGNs), and to construct a combined model integrating clinical risk factors for optimizing individualized treatment decisions.

Methods

We retrospectively collected imaging and clinical data from 630 patients with pathologically confirmed ground-glass nodules (GGNs) who underwent surgical resection at two medical centers between January 2020 and December 2024. Patients from Center 1 were randomly divided into training and internal validation sets at a 7:3 ratio, while patients from Center 2 served as the external validation set. Tumor habitats were

SUBMITTER: Dong N 

PROVIDER: S-EPMC12568381 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature